Joint Project Seeks to Model Predictive Control of Bioprocess Development and Scale-up

At the Emerson Global Users Exchange in Dallas earlier this month, Emerson Process Management and Broadley-James Corp., an Irvine, Calif.-based manufacturer of sensors and bioreactors, announced an intriguing partnership: The two vendors are working together to develop and test a model for predictive, in-line control of mammalian cell culture, from development through scale-up. Their ambitious goal is to create a "high-fidelity" model that would yield consistently high-quality proteins regardless of whether the batch size was 2L, 20L or even 2,000L.