Here, the role of chemically defined (CD) fermentation media in revolutionizing microbial bioproduction with Escherichia coli (E. coli) is explored. Historically, E. coli cultures have been widely used for recombinant protein expression and plasmid DNA preparation, but the options for growth media have been limited compared to eukaryotic production systems. However, the development of CD media has provided a well-defined nutritional composition, reducing variability and improving process consistency, while avoiding the use of animal origin components. Learn more about how the development of CD fermentation media provides new opportunities for E. coli in the manufacturing of next-generation biopharmaceuticals.
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